Gouri Import Latest: World’s First Liquid PCL ‘Gouri’ – Full Overview & Ellanse Comparison | TASAKI PHAMA

What is Gouri? Basics and Features of PCL Formulations

PCL (polycaprolactone) formulations have been gaining attention in the field of aesthetic medicine in recent years. Among them, ‘Gouri,’ which appeared as the world’s first fully liquid PCL formulation, has different characteristics from conventional PCL formulations and is attracting attention as a new option. TASAKI PHARMA provides information on importing this innovative formulation.

PCL is a biodegradable polymer compound that has been used for many years in the medical field as a base material for sutures and sustained-release drugs. By injecting it into the skin, it promotes collagen production and is expected to improve skin firmness and elasticity. Conventional PCL formulations mainly involved injecting particulate PCL as a suspension, but Gouri achieves more uniform injection and a natural finish by completely liquefying PCL with a special technology.

The main features of Gouri are as follows:

• Fully Liquid PCL: Compared to conventional particulate PCL formulations, there is less resistance during injection and uniform dispersion is possible.
• Collagen Production Promotion: PCL gradually decomposes in the subcutaneous tissue, promoting collagen production over the long term.
• Natural Volume Up: Because it promotes the regeneration of autologous tissue, it does not have an immediate volume-up effect like hyaluronic acid injections, but natural and long-term improvement can be expected.

Types of PCL Formulations

Various products other than Gouri are sold as formulations containing PCL as the main ingredient. A typical example is Ellanse. Ellanse is a formulation in which PCL particles are suspended in carboxymethylcellulose (CMC) gel, and it has the effect of promoting collagen production like Gouri, but there are differences in the form of the formulation and the duration of the effect.

Differences between Gouri and Ellanse: Ingredients, Effects, and Duration

Gouri and Ellanse are both formulations containing PCL as the main ingredient, but there are some differences in their characteristics. By understanding these differences, you can select the appropriate formulation to suit the patient’s condition and wishes.

First, regarding the ingredients, Gouri is a formulation in which only PCL is liquefied, whereas Ellanse is a formulation in which PCL particles are suspended in CMC gel. This difference affects the sensation during injection and the appearance of the effect. Because Gouri is liquid, it has less resistance during injection and is more easily dispersed evenly over a wider area. On the other hand, because Ellanse is gel-like, it tends to stay at the injection site and easily adds volume to specific areas.

Regarding the effects, both can be expected to promote collagen production and improve skin firmness and elasticity, but there is a difference in the duration of the effect. Ellanse can adjust the duration of the effect depending on the molecular weight of PCL and the type of CMC gel. In general, a duration of about 1 to 4 years can be expected. On the other hand, the duration of the effect of Gouri varies depending on the concentration of PCL and the injection method, but in general, a duration of about half a year to 1 year can be expected.

In addition, Ellanse may be associated with a risk of nodule formation after injection. This is thought to be due to the aggregation of PCL particles to form lumps. On the other hand, Gouri is thought to have a low risk of nodule formation because PCL is completely liquefied.

Comparison of Gouri and Ellanse

Gouri Injection Method and Effects: Mechanism of Overall Facial Lift

Gouri can be injected evenly over the entire face to promote collagen production and provide a natural lifting effect. Rather than adding volume to specific areas like conventional hyaluronic acid injections, it promotes the regeneration of autologous tissue, balancing the entire face and restoring a youthful appearance.

The injection method of Gouri varies depending on the doctor’s skill and experience, but in general, it is injected finely so that it is evenly distributed over the entire face. The injection sites cover the entire face, including the forehead, cheeks, and chin. The injection depth is generally in the shallow layer of the subcutaneous tissue. This allows PCL to gradually decompose within the subcutaneous tissue and promote collagen production.

The lifting effect of Gouri injection does not appear immediately after injection. It takes several weeks to months for PCL to decompose and collagen to be produced. However, once collagen is produced, its effect lasts relatively long. In order to maximize the effect of Gouri, it is important to select an appropriate injection method and an injection amount that matches the patient’s skin condition.

We also provide information on the proper use of Gouri. Our expert staff will carefully respond to questions and consultations from medical institutions.

Mechanism of Lift-Up by Gouri

1. Inject Gouri into subcutaneous tissue
2. PCL is gradually decomposed and stimulates fibroblasts
3. Fibroblasts produce collagen, elastin, and hyaluronic acid
4. Skin firmness, elasticity, and water retention are improved
5. Overall facial sagging is improved and a lifting effect appears

Safety and Future Prospects of PCL Formulations

PCL formulations are known as highly biocompatible and safe formulations. PCL has been approved for medical use by public institutions such as the FDA (U.S. Food and Drug Administration) and EMA (European Medicines Agency). However, there is a risk of side effects with any formulation. The main side effects of PCL formulations include swelling, redness, pain, and bruising at the injection site. These side effects usually disappear naturally within a few days to a few weeks.

Future prospects for PCL formulations include further improvements in safety and efficacy. For example, by adjusting the molecular weight and concentration of PCL, it may be possible to adjust the duration of the effect or reduce the risk of side effects. In addition, the development of new formulations aimed at synergistic effects by blending ingredients other than PCL is also expected.

TASAKI PHARMA focuses on the potential of PCL formulations in the field of aesthetic medicine and will continue to meet the needs of medical institutions by providing the latest information and high-quality products.

Summary

Gouri is the world’s first fully liquid PCL formulation, has different characteristics from conventional PCL formulations, and is attracting attention as a new option. Compared to other PCL formulations such as Ellanse, it has less resistance during injection, allows for uniform dispersion, and is thought to have a low risk of nodule formation. By injecting it evenly over the entire face, it promotes collagen production and can be expected to have a natural lifting effect. PCL formulations are known as highly biocompatible and safe formulations, and further development in the field of aesthetic medicine is expected in the future.